Our Work

Laguna Honda Hospital Pharmacy Upgrades (HCAI)

Advanced Sterile Compounding Facility in Active Acute Care Environment
Forest Hill, SF
2025
SF Dept of Public Works/SF Dept of Public Health

Project Overview

Major renovation of Laguna Honda Hospital’s Pharmacy Compounding Room, transforming critical pharmaceutical infrastructure while maintaining continuous operations in a fully functioning acute medical facility. This complex project delivered a state-of-the-art sterile compounding suite meeting the highest standards for medication preparation and patient safety.

Scope of Work

Compounding Suite Renovation

  • Complete remodel of existing compounding room with USP 797/800 compliance
  • New ante room construction for proper gowning and material transfer
  • ISO-classified cleanroom environments with appropriate air pressure cascades
  • Seamless epoxy flooring and wall systems for infection control
  • Stainless steel casework and pharmaceutical-grade finishes

Mechanical Systems Overhaul

  • New dedicated rooftop air handling unit installed directly above pharmacy
  • Independent HVAC system providing precise temperature and humidity control
  • HEPA filtration and positive/negative pressure relationships
  • Complete ductwork distribution through occupied hospital spaces
  • Integration with building automation and monitoring systems

Critical Infrastructure

  • Pharmaceutical-grade lighting with cleanable fixtures
  • Specialized electrical systems for compounding equipment
  • Emergency power connections for uninterrupted operations
  • Pass-through chambers and material transfer systems
  • Advanced fire suppression and life safety coordination

Project Challenges

Active Hospital Operations

  • Construction within fully operational acute care facility
  • Coordination with 24/7 pharmacy operations and medication delivery
  • Strict infection control protocols and dust containment measures
  • Noise and vibration management in patient care areas
  • Rooftop equipment installation above active clinical spaces

Complex Systems Integration

  • Structural coordination for new rooftop equipment loads
  • Penetrations through multiple floors in occupied building
  • Tie-ins to existing building systems without service interruptions
  • HCAI permit coordination and inspection scheduling
  • Phased construction to maintain pharmacy functionality

Regulatory Compliance

  • Full HCAI approval process for healthcare facility modifications
  • USP 797/800 cleanroom certification requirements
  • Sterile compounding environmental testing and validation
  • Air balance verification and pressure cascade documentation
  • Final inspections with hospital and state authorities

Results

  • State-of-the-art sterile compounding facility operational
  • Zero interruption to critical medication preparation services
  • Enhanced patient safety through improved environmental controls
  • Full regulatory compliance and certification achieved
  • Rooftop mechanical installation completed without facility disruption
  • Modern pharmaceutical infrastructure supporting acute care mission

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